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INOCYBE

Inocybe is a large genus of agaric mushroom of the Inocybaceae family.
The epithet Inocybe translates from Latin to “fibrous hat”.

5 Strains
  • Inocybe aeruginascens

    INOCYBE AERUGINASCENS

    INOCYBE

    0 out of 5

    Potency Levels

    Moderate

    MO

    Potency Levels

    • MILD < 0.25%
    • MODERATE 0.25% - 0.75%
    • HIGH > 0.75% - 2%
    • EXTREMELY HIGH > 2%

    Moderate

    MO

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  • INOCYBE CORYDALINA

    INOCYBE CORYDALINA

    INOCYBE

    0 out of 5

    Potency Levels

    Mild

    M

    Potency Levels

    • MILD < 0.25%
    • MODERATE 0.25% - 0.75%
    • HIGH > 0.75% - 2%
    • EXTREMELY HIGH > 2%

    Mild

    M

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  • INOCYBE COELESTIUM

    INOCYBE COELESTIUM

    INOCYBE

    0 out of 5

    Potency Levels

    Mild

    M

    Potency Levels

    • MILD < 0.25%
    • MODERATE 0.25% - 0.75%
    • HIGH > 0.75% - 2%
    • EXTREMELY HIGH > 2%

    Mild

    M

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  • INOCYBE HAEMACTA

    INOCYBE HAEMACTA

    INOCYBE

    0 out of 5

    Potency Levels

    Mild

    M

    Potency Levels

    • MILD < 0.25%
    • MODERATE 0.25% - 0.75%
    • HIGH > 0.75% - 2%
    • EXTREMELY HIGH > 2%

    Mild

    M

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  • CONOCYBE SMITHII

    CONOCYBE SMITHII

    CONOCYBE-PHOLIOTINAINOCYBE

    0 out of 5

    Potency Levels

    Mild

    M

    Potency Levels

    • MILD < 0.25%
    • MODERATE 0.25% - 0.75%
    • HIGH > 0.75% - 2%
    • EXTREMELY HIGH > 2%

    Mild

    M

    Learn More

Members of this genus are known to live in the roots of vascular host plants. This mycorrhizal relationship with the root system of various plants makes Inocybe amongst the most highly adaptative type of mushrooms. After all, it is said that mycelium is the largest living organism on earth, like a fungal world wide web, also part of what some call the “wood wide web”.
With over 1400 species including a mixture of edible, psychoactive and poisonous mushrooms, this genus has the reputation of being a “mycological minefield”.
Even Dr. Daniel Stuntz, who spent several decades studying the genus and estimated 400-600 species, was only able to recognize approximately 150. This gives a good idea of the difficulty to accurately identify this genus even for the most experienced mycologists, over the span of a lifetime!
Though some species may be slightly lilac, Inocybes have the typical “little brown mushroom” morphology, with usually small conical caps flattening with age, and often a distinctive musty “spermatic” odor.
Out of the thousands of mushrooms included in this genus, only five are known to contain the psychoactive tryptamine alkaloids psilocin and psilocybin. These strains are Inocybe aeruginascens, I. corydalina var corydalina, I. corydalina var erinaceomorpha, I. coelestium, and I. haemacta.
Because most Inocybe contain muscarine, a toxic alkaloid that can cause convulsion and death, it is said few people have bio assayed psilocybin-active Inocybes; data more likely came from chemical analyses rather than from personal experience (which is a good thing!). Though, exceptionally, in the case of Inocybe aeruginascens, it was an unfortunate intoxication back in 1983, while mistaking the psychoactive mushroom to the common fairy ring mushroom Marismius oreades, that revealed for the first time the presence of psilocybin in this specie!
The unusual feature of this small mycorrhizal tabacco-coloured fungus is that it contains almost equal amounts of three serotonin-like hallucinogenic compounds: psilocybin, baeocystin, and aeruginascin (the latter compound is believed to modify the pharmacological action of psilocybin.)

Nonetheless, because with this genus, it is most likely that you will find one that is toxic, it is with no doubt advised to “psychonauts” to refrain from ingesting any Inocybes found growing naturally in the wild.
Because Inocybes are so ambiguous to identify, most have not been tested for their toxicity, edibility nor psilocybin activity. In his book Psilocybin Mushrooms of the World, Paul Stamet even refrains from associating any pictures to the genus. He also suggest that there is no reason to believe that muscarine and psilocybin should be mutually exclusive and wonders if someday, we will discover a specie that produces both.

What is aeruginascin?

Magic mushrooms contain several compounds including psilocybin, psilocin, norpsilocin, baeocystin, norbaeocystin, and aeruginascin.
Aeruginascin is analog to psilocybin and is also closely related to the frog skin toxin bufotenidine (5-HTQ), a potent 5-HT3 receptor agonist that binds to the 5-HT3 receptor with ten times the affinity of serotonin.
One of the rare mushrooms to contain aeruginascin is Inocybe aeruginascens.

Jochen Gartz, a German mycologist, chemist, and author of “Magic Mushrooms around the World” was the first to discover and name aeruginascin. Since the eighties, he has been closely studying this indole derivative and his research proposes that this compound, usually found in trace amounts, can modify the pharmacological action of psilocybin. Because he believes it to foster an always euphoric state (no bad trips), he believes it to be a better option than psilocybin for therapeutical use. To support his theory, he refers to fifty reported experiences, half of which were accidental intoxications, and notes that instead of “freaking out about dying”, the fungus-eaters reported overall peaceful, euphoric episodes, often with colourful mystical experiences and occasional Wood Lover Paralysis.
The fact that these accidental ingestions have never reported “dysphoric trips” help suspect that Inocybe aeruginascin has a unique entourage effect, that may be responsible for fostering a persistent “good trip” experience. Could the fact that aeruginascin does not ross the blood-brain-barrier be related to the always euphoric state phenomenon? Aren’t bad trips, though not ideal, essential to the psychedelic therapeutical process?
Some even suggest aeruginascin could be to psilocybin what CBD is to THC; in other words, a smoother option, with overall more “bodily” than psychoactive effects.
Meanwhile, researchers at a startup pharmaceutical company specializing in psychedelic drug research, in a quest to unlock the euphoria experienced from consuming magic mushrooms, started synthetizing aeruginascin. They named these synthetized tryptamines Amphoria and Propharia.
Amphoria, a synthetize version of the suspected active metabolite of aeruginiscin, has been witnessed to provoke two profound clinical effects: euphoria (from the Greek” “euphoros” meaning ‘to carry wellness”) and, temporary paralysis, also known in the psychedelic community as the “Wood Lover Paralysis.

Even if as of 2020, aeruginascin is mentioned in the scientific literature, the psychedelic discussion boards, or anecdotal reports, it remains an understudied psilocybin derivative and unfortunately, we can therefore not completely understand its contribution for psychedelic therapy. Nonetheless, we know it exists will keep a close eye on it.
Food for thought: If “bad trips” are no one’s favourites, are they an essential part of the therapeutical process? Could aeruginascin really be a better therapeutical option than psilocybin? If the entourage effect is so unique to each mushroom, can synthetized versions of psychedelic compounds be as effective for psychedelic therapy?

What is "Wood Lover Paralysis"?

Wood Lover Paralysis (WLP) is a short-term muscle weakness and/or paralysis condition that occurs several hours after consuming psilocybin mushrooms. This strange phenomenon has also been observed with consumption of the frog venom toxin bufotenidine, which has a very similar chemical structure to aeruginascin (a coumpound found in magic mushrooms).

With WLP, consumers describe legs suddenly stopping to function, facial numbness, eyes jumping away from the focus intended, body extremities tingling and an overall sensation of the bones and muscles losing strength. It has been observed that this mysterious state only occurs upon consumption of magic mushrooms that grow on wood, thus the name “wood lover paralysis”.

The species most often reported to cause WLP are Psilocybe cyanescens and Psilocybe azurescens, and to a lesser extent, P. stunzii, P. allenii, P. pelliculosa, P. ovoideocystidiata, P. subaeruginosa and P. aeruginascen.

While many hypotheses attempt to explain this unsolved mystery, it is suggested by the believers of the black rot theory that the build-up of histamines may be caused by bacteria who can produce histamines in spoiled food (especially fish, clams, mushrooms, etc.) and therefore explain why Benadryl, (a potent anti-muscarinic and anti-histaminic used to treat certain types of acute movement disorders) helps reduce the symptoms and regain muscle movement and strength.

While some suggest bacterial and/or microbial contaminations like black rot may be responsible for WLP, other studies have been exploring the unique compound aeruginascin, present at higher levels in Inocybe aeruginascen, another specie known to cause the WLP. The surprising similarity in the chemical structure of aeruginascin and the frog venom bufotenidine, has scientists wondering: could it be an entourage effect? Unfortunately to this day, there is no research on aeruginascin, its chemistry and its effects in conjunction with other compounds present in magic mushrooms. Therefore, the mystery of WLP to this day remains unsolved; between black rot, botulism, histamine, aeruginascin or just too much of a high dose, the enigma lives on.

Surely, these incredible fascinating wood-loving magic mushrooms, bridges between life and death, that are always problem solving, that don’t need light to survive, that grow from anything and communicate with all, that can even turn petroleum waste into fungus honey, surely, we ought not to be surprised that they can take over our bodily motor functions and for a few long minutes, disconnect us from our will to command movement, in stillness, like a tree.

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STRAINS

  • Mushroom Strains
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ABOUT

  • Contact

STRAINS

  • Mushroom Strains
  • Strain Types (Genus)
  • Strain Region
  • Wellness
  • Performance
  • Blog

ABOUT

  • Contact

STRAINS

  • Mushroom Strains
  • Strain Types (Genus)
  • Strain Region
  • Wellness
  • Performance
  • Blog

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